GPR174

Across TCGA cell cohorts, GPR174 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. KIDNEY shows the largest number of these associations.

The most reproducible GPR174-associated genes across cancer lineages are LCE3D, GDF3, and OR2W5. Each is linked with GPR174 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR174-to-partner and partner-to-GPR174 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE3D grouped by GPR174-low versus GPR174-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR174→partner) and Y-score (partner→GPR174) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	LCE3D →	+0.110	+5.000	<.001	.005	3	1
KIDNEY	GDF3 →	+0.020	+5.000	<.001	.005	3	1
KIDNEY	OR2W5 →	+0.026	+5.000	<.001	.005	3	1
KIDNEY	MROH5 →	+0.006	+5.000	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR2L5 →	+0.019	+4.887	<.001	.009	3	1
SKIN	HELT →	+0.057	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

LCE3D by GPR174 expression — KIDNEY

Explore this box plot interactively →