GPR158-AS1

Across TCGA pan-cancer cohorts, GPR158-AS1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated GPR158-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher GPR158-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GPR158-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.

ACC, KIRC, and KICH are the cancer types where GPR158-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.219	0.679	<.001	162	view →
KIRC	OS	Tertile	All	0.452	0.671	<.001	62	view →
KICH	OS	Tertile	II,III,IV	0.070	0.828	<.001	54	view →
HNSC	OS	Tertile	All	0.845	0.731	.010	42	view →
CESC	OS	Tertile	IV	0.271	0.649	.021	36	view →
SKCM	OS	Median	III,IV	0.252	0.468	.009	14	view →
ESCA	DFS	Median	III,IV	0.445	0.243	.022	13	view →
LGG	OS	Tertile	All	0.574	0.349	.004	12	view →
COAD	OS	Tertile	III,IV	0.478	0.804	.015	9	view →
LIHC	DFS	Tertile	III,IV	0.094	0.424	.003	9	view →
DLBC	DFS	Tertile	II,III,IV	0.890	0.561	.036	3	view →
MESO	DFS	Quartile	IV	0.166	0.412	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

GPR158-AS1–ACC (OS)

Open the ACC breakdown →