GPR157

Across TCGA patient cohorts, GPR157 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR157-associated genes across cancer lineages are ERK2, Shc_pY317, and Src_pY527. Each is linked with GPR157 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR157-to-partner and partner-to-GPR157 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by GPR157-low versus GPR157-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR157→partner) and Y-score (partner→GPR157) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.344	+3.000	.001	.037	2	1
UCEC	Shc_pY317 →	-0.351	-3.000	<.001	.037	1	1
UCEC	Src_pY527 →	-0.696	-3.000	.005	.037	1	1
UCEC	STAT3_pY705 →	-0.526	-3.000	<.001	.037	1	1
UCEC	Bax →	+0.284	+3.000	.040	.037	1	1
UCEC	Di-Ras3 →	-0.209	-3.000	.014	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ERK2 by GPR157 expression — UCEC

Explore this box plot interactively →