GPR157

Across TCGA pan-cancer cohorts, GPR157 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated GPR157 data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher GPR157 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GPR157 expression acts as an unfavorable survival marker, although some lineages such as SCLC and DLBC show a favorable association.

CESC, SCLC, and LGG are the cancer types where GPR157 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Quartile	II,III,IV	0.344	0.781	.008	70	view →
SCLC	DFS	Median	All	0.760	0.477	<.001	58	view →
LGG	OS	Median	All	0.707	0.906	<.001	53	view →
KICH	OS	Median	III,IV	0.766	1.000	.006	47	view →
LUAD	OS	Quartile	All	0.654	0.861	.001	47	view →
PAAD	OS	Median	All	0.410	0.641	.006	27	view →
LIHC	DFS	Tertile	All	0.389	0.649	.001	18	view →
SARC	OS	Tertile	All	0.584	0.836	.001	18	view →
SKCM	OS	Quartile	All	0.272	0.476	.002	17	view →
UCS	OS	Median	III,IV	0.419	0.742	.010	14	view →
BRCA	DFS	Quartile	All	0.506	0.691	.014	13	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GPR157–CESC (OS)

Open the CESC breakdown →