GPR157

Across TCGA cell cohorts, GPR157 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,714 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GPR157-associated GO terms across cancer lineages are Positive regulation of proteasomal ubiquitin-dependent protein catabolic process, Negative regulation of protein-containing complex assembly, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with GPR157 in more than 11 cancer types. Because this analysis shows association rather than direction, both GPR157-to-partner and partner-to-GPR157 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of proteasomal ubiquitin-dependent protein catabolic process grouped by GPR157-low versus GPR157-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR157→partner) and Y-score (partner→GPR157) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.083	+1.915	<.001	<.001	3	12
LARGE_INTESTINE	Negative regulation of protein-containing complex assembly →	+0.079	+1.824	<.001	<.001	3	11
LARGE_INTESTINE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.136	+1.318	.003	.005	3	11
STOMACH	Purine nucleoside triphosphate metabolic process →	+0.088	+1.472	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.068	+1.210	<.001	.003	3	10
PANCREAS	Regulation of protein localization to endoplasmic reticulum →	+0.141	+1.659	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,714 associations by consensus.

Positive regulation of proteasomal ubiquitin-dependent protein catabolic process by GPR157 expression — BLOOD_Lymphoma

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