GPR157

Across TCGA cell cohorts, GPR157 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible GPR157-associated genes across cancer lineages are SPATA48, GAGE12H, and DEFA1. Each is linked with GPR157 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR157-to-partner and partner-to-GPR157 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA48 grouped by GPR157-low versus GPR157-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR157→partner) and Y-score (partner→GPR157) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SPATA48 →	+0.008	+4.222	<.001	.006	3	1
OVARY	GAGE12H →	+0.321	+3.990	<.001	.003	3	1
LARGE_INTESTINE	DEFA1 →	+0.389	+3.920	<.001	.005	3	1
OVARY	DIPK2B →	+0.333	+4.209	<.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

SPATA48 by GPR157 expression — OVARY

Explore this box plot interactively →