GPR156

Across TCGA patient cohorts, GPR156 mutation is significantly associated with the RNA expression of many other genes, with 6,022 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR156-associated genes across cancer lineages are RPS6KB1, SMPD4, and PHB. Each is linked with GPR156 in more than 3 cancer types. Because this analysis shows association rather than direction, both GPR156-to-partner and partner-to-GPR156 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS6KB1 grouped by GPR156-low versus GPR156-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR156→partner) and Y-score (partner→GPR156) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS6KB1 →	+0.430	+2.485	<.001	<.001	3	4
UCEC	SMPD4 →	+0.502	+1.903	<.001	<.001	3	4
UCEC	PHB →	+0.402	+2.169	.004	<.001	3	4
UCEC	LPIN2 →	+0.424	+1.928	.007	.008	3	3
LUSC	SMCHD1 →	+0.672	+3.217	.001	.009	3	3
UCEC	CEP76 →	+0.514	+2.496	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,022 associations by consensus.

RPS6KB1 by GPR156 expression — UCEC

Explore this box plot interactively →