GPR156

Across TCGA pan-cancer cohorts, GPR156 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GPR156’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GPR156 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPR156 is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where GPR156 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR156 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.711	<.001	8	view →
THCA	All	All	+0.080	<.001	7	view →
LIHC	All	All	+0.035	<.001	6	view →
LUSC	All	All	+0.835	<.001	5	view →
COAD	Female	IV	−0.035	.019	3	view →
BLCA	Male	IV	−1.572	.005	2	view →
READ	All	All	−0.426	.025	2	view →
PRAD	All	All	−0.331	<.001	2	view →
CHOL	All	All	+0.094	<.001	2	view →
LUAD	All	All	+0.231	.039	1	view →
KIRC	Female	All	−0.162	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GPR156–HNSC

Open the HNSC breakdown →