GPR156

Across TCGA patient cohorts, GPR156 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR156-associated genes across cancer lineages are PDCD4, ER-alpha, and FoxM1. Each is linked with GPR156 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR156-to-partner and partner-to-GPR156 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by GPR156-low versus GPR156-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR156→partner) and Y-score (partner→GPR156) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.689	-3.077	<.001	<.001	3	3
UCEC	ER-alpha →	-0.667	-1.514	.017	.015	3	2
UCEC	FoxM1 →	+0.213	+1.807	.015	.004	3	2
UCEC	JNK_pT183_Y185 →	-0.203	-2.124	<.001	.001	3	2
UCEC	Notch1 →	+0.184	+2.235	<.001	.005	3	2
UCEC	Rictor_pT1135 →	-0.072	-1.247	.038	.045	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

PDCD4 by GPR156 expression — UCEC

Explore this box plot interactively →