GPR155

Across TCGA patient cohorts, GPR155 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR155-associated genes across cancer lineages are eEF2, PCNA, and Shc_pY317. Each is linked with GPR155 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR155-to-partner and partner-to-GPR155 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GPR155-low versus GPR155-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR155→partner) and Y-score (partner→GPR155) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.243	+1.201	.028	.028	3	2
UCEC	PCNA →	+0.232	+2.169	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.176	-1.893	<.001	<.001	3	2
UCEC	Smad3 →	+0.121	+1.440	.009	.022	3	2
UCEC	ASNS →	+0.355	+1.201	.001	.028	3	2
UCEC	Cyclin-B1 →	+0.800	+2.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

eEF2 by GPR155 expression — UCEC

Explore this box plot interactively →