GPR155

Across TCGA pan-cancer cohorts, GPR155 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GPR155’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GPR155 RNA is repressed in tumor relative to normal tissue. In most cancer types GPR155 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and THCA are the cancer types where GPR155 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR155 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.168	<.001	12	view →
KIRP	Male	III,IV	−2.232	<.001	11	view →
THCA	All	IV	−1.877	<.001	11	view →
KICH	All	II,III,IV	−1.300	<.001	10	view →
STAD	Male	All	−1.511	<.001	9	view →
HNSC	Female	III,IV	+0.970	<.001	8	view →
BLCA	All	IV	−1.487	.002	6	view →
UCEC	All	All	−0.766	<.001	6	view →
BRCA	All	III,IV	−0.426	.001	6	view →
LIHC	All	All	+0.479	<.001	5	view →
COAD	Male	II,III,IV	−0.552	.039	3	view →
PAAD	Female	All	−0.709	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GPR155–KIRC

Open the KIRC breakdown →