GPR152

Across TCGA patient cohorts, GPR152 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR152-associated genes across cancer lineages are ASNS, Beclin, and p62 Lck ligand. Each is linked with GPR152 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR152-to-partner and partner-to-GPR152 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by GPR152-low versus GPR152-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR152→partner) and Y-score (partner→GPR152) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.499	+3.008	.015	.019	3	1
COAD	Beclin →	-0.185	-2.991	.028	.036	3	1
UCEC	p62 Lck ligand →	+0.446	+3.009	.008	.019	3	1
UCEC	Annexin-1 →	+0.819	+3.189	.002	.010	3	1
UCEC	VEGFR2 →	+0.361	+2.183	.020	.035	3	1
COAD	Caspase-7-cleavedD198 →	+1.184	+3.008	.003	.019	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ASNS by GPR152 expression — COAD

Explore this box plot interactively →