GPR152

Across TCGA pan-cancer cohorts, GPR152 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GPR152 data layer compared with 6 for mutation status.

The strongest signal is observed in brain lower grade glioma (LGG), where higher GPR152 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPR152 expression acts as an unfavorable survival marker, although some lineages such as SCLC and SKCM show a favorable association.

LGG, COAD, and TGCT are the cancer types where GPR152 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.301	0.496	<.001	38	view →
COAD	OS	Tertile	All	0.813	0.888	.009	34	view →
TGCT	OS	Tertile	III,IV	0.501	1.000	.014	26	view →
SCLC	DFS	Median	II,III,IV	0.984	0.427	.009	24	view →
KIRC	OS	Median	All	0.552	0.743	<.001	24	view →
SKCM	OS	Median	All	0.873	0.724	.005	23	view →
UCS	DFS	Tertile	III,IV	0.545	0.157	.015	20	view →
OV	DFS	Median	IV	0.221	0.388	.031	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
THCA	OS	Tertile	IV	0.751	1.000	.014	18	view →
STAD	DFS	Tertile	IV	0.743	0.130	.023	13	view →
BRCA	DFS	Quartile	III,IV	0.811	0.889	.030	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GPR152–LGG (DFS)

Open the LGG breakdown →