GPR146

Across TCGA cell cohorts, GPR146 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPR146-associated genes across cancer lineages are VN1R4, PNLIPRP2, and TARM1. Each is linked with GPR146 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR146-to-partner and partner-to-GPR146 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R4 grouped by GPR146-low versus GPR146-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR146→partner) and Y-score (partner→GPR146) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	VN1R4 →	+0.098	+5.754	<.001	.002	3	1
CNS	PNLIPRP2 →	+0.102	+4.981	<.001	.008	3	1
BLOOD_Lymphoma	TARM1 →	+0.021	+4.643	<.001	.005	3	1
BLOOD_Leukemia	C20orf85 →	+0.049	+5.969	<.001	.001	3	1
BLOOD_Leukemia	IL22 →	+0.050	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	KRTAP4-6 →	+0.048	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

VN1R4 by GPR146 expression — CNS

Explore this box plot interactively →