GPR142

Across TCGA pan-cancer cohorts, GPR142 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated GPR142 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher GPR142 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPR142 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

BRCA, UCEC, and HNSC are the cancer types where GPR142 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.575	0.950	<.001	36	view →
UCEC	DFS	Median	All	1.000	0.827	.007	32	view →
HNSC	OS	Median	II,III,IV	0.086	0.711	<.001	18	view →
ACC	OS	Median	All	0.214	0.802	.002	15	view →
LUAD	OS	Median	II,III,IV	0.141	0.677	.002	6	view →
SKCM	OS	Median	All	0.969	0.866	.026	5	view →
GBM	DFS	Median	All	0.066	0.244	.007	3	view →
COAD	OS	Median	II,III,IV	0.497	0.788	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

GPR142–BRCA (DFS)

Open the BRCA breakdown →