Across TCGA cell cohorts, GPR141 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR141-associated genes across cancer lineages are HAO1, OR12D3, and GHRH. Each is linked with GPR141 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR141-to-partner and partner-to-GPR141 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR141→partner) and Y-score (partner→GPR141) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	HAO1 →	+0.023	+4.906	<.001	.006	3	1
LARGE_INTESTINE	OR12D3 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	GHRH →	+0.159	+4.099	.001	<.001	3	1
LARGE_INTESTINE	TAS2R7 →	+0.011	+4.022	<.001	.006	3	1
LARGE_INTESTINE	KCNK17 →	+0.106	+3.906	<.001	.002	3	1
LARGE_INTESTINE	GPR42 →	+0.003	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

GPR141 survival (RNA) · tumor vs normal (RNA) · all GPR141 data types