GPR137B

Across TCGA patient cohorts, GPR137B mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR137B-associated genes across cancer lineages are EGFR_pY1068, Gab2, and Ku80. Each is linked with GPR137B in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR137B-to-partner and partner-to-GPR137B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GPR137B-low versus GPR137B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR137B→partner) and Y-score (partner→GPR137B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.222	-2.700	.049	.006	3	1
UCEC	Gab2 →	+0.464	+3.169	.003	.019	3	1
UCEC	Ku80 →	+0.350	+3.820	<.001	<.001	3	1
UCEC	MAPK_pT202_Y204 →	-0.567	-2.459	.007	.019	3	1
UCEC	MEK1_p_S217_S221 →	-0.257	-2.321	.036	.034	3	1
UCEC	MEK1 →	+0.397	+2.700	.016	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by GPR137B expression — UCEC

Explore this box plot interactively →