GPR137B

Across TCGA pan-cancer cohorts, GPR137B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated GPR137B data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GPR137B RNA is associated with better overall survival. In most high-consensus cancer types, elevated GPR137B expression acts as an unfavorable survival marker, although some lineages such as KIRC and PAAD show a favorable association.

KIRC, ACC, and SCLC are the cancer types where GPR137B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.717	0.535	<.001	64	view →
ACC	DFS	Median	All	0.249	0.664	<.001	58	view →
SCLC	OS	Tertile	II,III,IV	0.323	0.684	.004	21	view →
PAAD	DFS	Tertile	II,III,IV	0.563	0.309	.003	18	view →
ESCA	DFS	Tertile	II,III,IV	1.000	0.200	.005	18	view →
READ	OS	Tertile	III,IV	0.597	0.848	.014	12	view →
LGG	DFS	Tertile	All	0.588	0.343	.010	12	view →
LUAD	DFS	Quartile	All	0.514	0.303	.022	11	view →
MESO	OS	Median	II,III,IV	0.496	0.299	.008	7	view →
UVM	DFS	Tertile	III,IV	0.441	0.878	.010	6	view →
CHOL	OS	Quartile	All	0.838	0.285	.014	6	view →
THYM	OS	Median	All	0.917	1.000	.007	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GPR137B–KIRC (OS)

Open the KIRC breakdown →