GPR135

Across TCGA patient cohorts, GPR135 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,357 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GPR135-associated proteins across cancer lineages are DNAL1, TXNDC5, and PHACTR2. Each is linked with GPR135 in more than 4 cancer types. Because this analysis shows association rather than direction, both GPR135-to-partner and partner-to-GPR135 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPR135 versus DNAL1 in OV, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR135→partner) and Y-score (partner→GPR135) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DNAL1 →	+0.600	+0.592	.006	.003	3	4
BRCA	TXNDC5 →	-0.441	-0.361	.001	.005	2	5
PDAC	PHACTR2 →	-0.320	-0.288	<.001	.002	3	4
LUAD	SEC23B →	-0.334	-0.599	<.001	<.001	3	4
BRCA	EDEM3 →	-0.213	-0.428	<.001	<.001	3	4
GBM	RPL26 →	-0.770	-0.624	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,357 associations by consensus.

GPR135 vs DNAL1 — OV

Explore this scatter interactively →