GPR135

Across TCGA patient cohorts, GPR135 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR135-associated genes across cancer lineages are Rictor_pT1135, beta-Catenin, and Caspase-7-cleavedD198. Each is linked with GPR135 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR135-to-partner and partner-to-GPR135 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by GPR135-low versus GPR135-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR135→partner) and Y-score (partner→GPR135) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.105	-3.584	.010	.002	3	2
UCEC	beta-Catenin →	+0.664	+3.807	.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.503	+2.341	.035	.019	3	2
UCEC	Cyclin-B1 →	+0.626	+2.321	.005	.033	3	2
UCEC	Di-Ras3 →	-0.162	-3.156	.006	.018	3	2
UCEC	EGFR_pY1068 →	-0.351	-1.906	<.001	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Rictor_pT1135 by GPR135 expression — UCEC

Explore this box plot interactively →