GPR135

Across TCGA cell cohorts, GPR135 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR135-associated genes across cancer lineages are SPIC, ITGAD, and LCE1D. Each is linked with GPR135 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR135-to-partner and partner-to-GPR135 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPIC grouped by GPR135-low versus GPR135-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR135→partner) and Y-score (partner→GPR135) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPIC →	+0.177	+2.925	<.001	.007	3	2
LARGE_INTESTINE	ITGAD →	+0.014	+3.832	<.001	<.001	3	1
LARGE_INTESTINE	LCE1D →	+0.247	+3.217	<.001	.006	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.008	+3.700	<.001	.009	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.017	+4.662	<.001	.005	3	1
LARGE_INTESTINE	C16orf96 →	+0.516	+3.520	.003	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SPIC by GPR135 expression — LARGE_INTESTINE

Explore this box plot interactively →