GPR119

Across TCGA patient cohorts, GPR119 mutation is significantly associated with the RNA expression of many other genes, with 973 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR119-associated genes across cancer lineages are LARP7P1, RNU6-796P, and OR8B6P. Each is linked with GPR119 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR119-to-partner and partner-to-GPR119 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LARP7P1 grouped by GPR119-low versus GPR119-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR119→partner) and Y-score (partner→GPR119) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LARP7P1 →	+0.213	+7.051	<.001	<.001	3	2
LUAD	RNU6-796P →	+0.415	+3.491	<.001	.008	3	2
LUAD	OR8B6P →	+0.029	+4.315	<.001	.007	3	2
LUAD	RN7SL96P →	+0.136	+3.531	<.001	.007	3	2
UCEC	SMIM10 →	-0.605	-3.576	.003	.002	3	2
UCEC	VTRNA2-2P →	+0.350	+1.981	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 973 associations by consensus.

LARP7P1 by GPR119 expression — BLCA

Explore this box plot interactively →