GPR119

Across TCGA pan-cancer cohorts, GPR119 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated GPR119 data layer compared with 2 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher GPR119 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GPR119 expression acts as an unfavorable survival marker, although some lineages such as SKCM and PAAD show a favorable association.

KIRP, DLBC, and SKCM are the cancer types where GPR119 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.820	0.953	.001	75	view →
DLBC	DFS	Tertile	II,III,IV	0.065	0.829	<.001	72	view →
SKCM	DFS	Tertile	II,III,IV	0.488	0.192	.001	69	view →
UCEC	DFS	Tertile	III,IV	0.328	0.598	.007	36	view →
COAD	OS	Tertile	III,IV	0.246	0.701	.008	33	view →
PAAD	DFS	Quartile	All	0.463	0.205	.008	21	view →
UCS	DFS	Tertile	III,IV	0.619	0.163	.017	18	view →
PCPG	DFS	Tertile	All	0.378	0.856	.006	18	view →
ACC	DFS	Tertile	All	0.112	0.544	.042	9	view →
LGG	OS	Tertile	All	0.298	0.540	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

GPR119–KIRP (OS)

Open the KIRP breakdown →