GPR119

Across TCGA cell cohorts, GPR119 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR119-associated genes across cancer lineages are OR10A4, OR4F21, and FAM153B. Each is linked with GPR119 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR119-to-partner and partner-to-GPR119 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A4 grouped by GPR119-low versus GPR119-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR119→partner) and Y-score (partner→GPR119) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10A4 →	+0.063	+3.938	<.001	.002	3	1
LARGE_INTESTINE	OR4F21 →	+0.209	+3.878	<.001	.003	3	1
LARGE_INTESTINE	FAM153B →	+0.644	+3.748	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR10A4 by GPR119 expression — LARGE_INTESTINE

Explore this box plot interactively →