GPR108

Across TCGA patient cohorts, GPR108 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,565 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible GPR108-associated proteins across cancer lineages are SH2D3A_S147, SH2D3A_S180, and CAMSAP3. Each is linked with GPR108 in more than 4 cancer types. Because this analysis shows association rather than direction, both GPR108-to-partner and partner-to-GPR108 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPR108 versus SH2D3A_S147 in LUAD, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR108→partner) and Y-score (partner→GPR108) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SH2D3A_S147 →	+0.434	+0.262	<.001	<.001	3	5
OV	SH2D3A_S180 →	+0.905	+0.591	<.001	<.001	3	5
OV	CAMSAP3 →	+0.442	+0.697	.001	.001	3	5
LUAD	SH2D3A_S218 →	+0.628	+0.268	<.001	<.001	3	4
OV	CAMSAP3_S334 →	+0.670	+0.685	<.001	<.001	3	4
LUAD	MICALL2_S649 →	-0.419	-0.265	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,565 associations by consensus.

GPR108 vs SH2D3A_S147 — LUAD

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