GPR108

Across TCGA pan-cancer cohorts, GPR108 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of GPR108’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where GPR108 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPR108 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

LIHC, KICH, and LUSC are the cancer types where GPR108 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPR108 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.116	<.001	9	view →
KICH	Female	II,III,IV	−0.885	<.001	8	view →
LUSC	Male	All	−0.419	<.001	7	view →
UCEC	All	All	−0.485	<.001	6	view →
LUAD	All	All	−0.319	<.001	6	view →
KIRC	Female	All	+0.387	<.001	4	view →
COAD	All	II,III,IV	−0.277	.004	4	view →
CHOL	Female	All	+2.156	<.001	3	view →
ESCA	All	All	+0.471	.026	1	view →
STAD	Male	II,III,IV	+0.359	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

GPR108–LIHC

Open the LIHC breakdown →