GPR108

Across TCGA patient cohorts, GPR108 mutation is significantly associated with the RNA expression of many other genes, with 1,024 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR108-associated genes across cancer lineages are RNA5SP414, MTND5P35, and RNA5SP412. Each is linked with GPR108 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR108-to-partner and partner-to-GPR108 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by GPR108-low versus GPR108-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR108→partner) and Y-score (partner→GPR108) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.628	+2.670	<.001	<.001	3	2
CESC	MTND5P35 →	+0.035	+5.539	<.001	.004	3	2
UCEC	RNA5SP412 →	+0.600	+2.074	<.001	.004	3	2
SKCM	UTP15 →	+0.525	+3.706	.004	<.001	3	2
SKCM	CKAP2L →	+0.779	+3.350	.005	.005	3	2
SKCM	MTHFD2P7 →	+0.083	+3.220	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,024 associations by consensus.

RNA5SP414 by GPR108 expression — UCEC

Explore this box plot interactively →