GPR108

Across TCGA patient cohorts, GPR108 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR108-associated genes across cancer lineages are MEK1, Caspase-7-cleavedD198, and A-Raf_pS299. Each is linked with GPR108 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR108-to-partner and partner-to-GPR108 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by GPR108-low versus GPR108-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR108→partner) and Y-score (partner→GPR108) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.371	+2.321	.014	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.583	+2.341	.017	.019	3	2
UCEC	A-Raf_pS299 →	-0.129	-2.321	.009	.034	3	1
UCEC	ERK2 →	+0.170	+3.169	.032	.018	3	1
UCEC	GAPDH →	+0.446	+2.999	.044	.035	3	1
UCEC	p62 Lck ligand →	+0.485	+3.000	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MEK1 by GPR108 expression — UCEC

Explore this box plot interactively →