GPR108

Across TCGA cell cohorts, GPR108 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,265 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GPR108-associated GO terms across cancer lineages are Autophagy, Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Maturation of SSU-rRNA. Each is linked with GPR108 in more than 11 cancer types. Because this analysis shows association rather than direction, both GPR108-to-partner and partner-to-GPR108 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Autophagy grouped by GPR108-low versus GPR108-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR108→partner) and Y-score (partner→GPR108) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Autophagy →	+0.061	+0.672	<.001	.001	3	12
KIDNEY	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	-0.095	-0.905	.008	<.001	3	12
BLOOD_Myeloma	Maturation of SSU-rRNA →	-0.096	-0.578	.004	.005	3	12
UPPER_AERODIGESTIVE_TRACT	Process utilizing autophagic mechanism →	+0.061	+0.672	<.001	.001	3	12
LUNG_SCLC	Regulation of cyclin-dependent protein serine/threonine kinase activity →	-0.094	-1.528	.002	.008	3	11
SOFT_TISSUE	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	-0.109	-0.689	.002	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,265 associations by consensus.

Autophagy by GPR108 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →