GPR108

Across TCGA cell cohorts, GPR108 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GPR108-associated genes across cancer lineages are WDR87, OR2T1, and OR1D5. Each is linked with GPR108 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR108-to-partner and partner-to-GPR108 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR87 grouped by GPR108-low versus GPR108-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR108→partner) and Y-score (partner→GPR108) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	WDR87 →	+0.020	+4.095	<.001	.009	3	1
SKIN	OR2T1 →	+0.010	+5.022	<.001	.002	3	1
SKIN	OR1D5 →	+0.017	+5.022	<.001	.002	3	1
SKIN	C7orf77 →	+0.111	+4.415	<.001	.007	3	1
LUNG_NSCLC_LUAD	RBMY1F →	+0.204	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	NLRP13 →	+0.006	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

WDR87 by GPR108 expression — SKIN

Explore this box plot interactively →