GPR101

Across TCGA patient cohorts, GPR101 mutation is significantly associated with the RNA expression of many other genes, with 1,706 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR101-associated genes across cancer lineages are MRPL19, SKA1, and TIPIN. Each is linked with GPR101 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR101-to-partner and partner-to-GPR101 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL19 grouped by GPR101-low versus GPR101-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR101→partner) and Y-score (partner→GPR101) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MRPL19 →	+0.394	+3.239	.005	.008	3	3
UCEC	SKA1 →	+0.691	+2.439	<.001	.001	3	3
UCEC	TIPIN →	+0.425	+2.343	.002	<.001	3	3
UCEC	CCDC163 →	+0.467	+2.616	.001	.005	3	3
UCEC	TAF13 →	+0.559	+1.925	.002	.005	3	3
UCEC	WDHD1 →	+0.596	+2.439	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,706 associations by consensus.

MRPL19 by GPR101 expression — LUAD

Explore this box plot interactively →