GPR101

Across TCGA pan-cancer cohorts, GPR101 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated GPR101 data layer compared with 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher GPR101 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPR101 expression acts as an unfavorable survival marker, although some lineages such as LGG and LIHC show a favorable association.

LUSC, KIRC, and DLBC are the cancer types where GPR101 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Quartile	III,IV	0.167	0.678	.005	64	view →
KIRC	DFS	Tertile	IV	0.250	0.642	<.001	54	view →
DLBC	DFS	Median	IV	0.223	1.000	.001	46	view →
LGG	DFS	Median	All	0.880	0.784	<.001	40	view →
LIHC	OS	Median	III,IV	0.472	0.277	.013	26	view →
UCEC	DFS	Tertile	All	0.509	0.665	.010	18	view →
PRAD	OS	Median	All	1.000	0.793	.004	16	view →
KIRP	DFS	Tertile	III,IV	0.635	0.260	.023	13	view →
ACC	DFS	Tertile	IV	0.172	0.450	.028	9	view →
MESO	OS	Tertile	IV	0.243	0.646	.042	9	view →
SCLC	OS	Quartile	All	0.498	0.898	.009	9	view →
SKCM	OS	Tertile	II,III,IV	0.768	0.856	.007	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

GPR101–LUSC (DFS)

Open the LUSC breakdown →