GPR101

Across TCGA patient cohorts, GPR101 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR101-associated genes across cancer lineages are mTOR_pS2448, INPP4B, and JNK_pT183_Y185. Each is linked with GPR101 in more than 3 cancer types. Because this analysis shows association rather than direction, both GPR101-to-partner and partner-to-GPR101 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by GPR101-low versus GPR101-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR101→partner) and Y-score (partner→GPR101) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	mTOR_pS2448 →	-0.244	-3.000	.019	.036	3	3
COAD	INPP4B →	-0.426	-3.000	.015	.035	3	3
COAD	JNK_pT183_Y185 →	-0.244	-3.000	.046	.035	3	3
LUAD	Tuberin_pT1462 →	-0.211	-3.000	.039	.036	3	2
LUAD	Bap1-c-4 →	+0.246	+2.832	.018	.034	3	2
UCEC	MEK1 →	+0.356	+2.999	.018	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

mTOR_pS2448 by GPR101 expression — LUAD

Explore this box plot interactively →