GPNMB

Across TCGA pan-cancer cohorts, GPNMB mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GPNMB data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GPNMB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPNMB expression acts as an unfavorable survival marker.

COAD, UCEC, and CCRCC are the cancer types where GPNMB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.909	1.000	.010	60	view →
UCEC	OS	Tertile	All	0.825	0.974	.018	22	view →
CCRCC	DFS	Quartile	III,IV	0.354	0.837	.002	14	view →
GBM	OS	Median	All	0.808	0.903	.031	8	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	6	view →
LSCC	OS	Tertile	All	0.692	1.000	.043	3	view →
HNSC	DFS	Median	IV	0.920	1.000	.028	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GPNMB–COAD (DFS)

Open the COAD breakdown →