GPNMB

Across TCGA patient cohorts, GPNMB protein abundance is significantly associated with the RNA expression of many other genes, with 11,945 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GPNMB-associated genes across cancer lineages are HTRA4, NPL, and FTL. Each is linked with GPNMB in more than 8 cancer types. Because this analysis shows association rather than direction, both GPNMB-to-partner and partner-to-GPNMB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPNMB versus HTRA4 in CCRCC, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPNMB→partner) and Y-score (partner→GPNMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HTRA4 →	+1.122	+0.891	<.001	<.001	3	9
HNSC	NPL →	+1.024	+0.793	<.001	<.001	3	8
GBM	FTL →	+1.026	+1.175	<.001	<.001	3	8
OV	LY86 →	+1.122	+0.660	.003	.009	3	7
UCEC	LILRB4 →	+1.355	+0.804	<.001	.002	3	7
CCRCC	HS3ST2 →	+1.272	+0.777	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,945 associations by consensus.

GPNMB vs HTRA4 — CCRCC

Explore this scatter interactively →