GPNMB

Across TCGA patient cohorts, GPNMB mutation is significantly associated with the RNA expression of many other genes, with 4,507 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPNMB-associated genes across cancer lineages are BUB3, TSPAN7, and GFM2. Each is linked with GPNMB in more than 2 cancer types. Because this analysis shows association rather than direction, both GPNMB-to-partner and partner-to-GPNMB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by GPNMB-low versus GPNMB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPNMB→partner) and Y-score (partner→GPNMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.569	+3.245	<.001	<.001	3	3
UCEC	TSPAN7 →	-0.998	-1.989	.001	.001	3	3
UCEC	GFM2 →	+0.713	+3.174	<.001	<.001	3	3
COAD	GPHN →	+0.863	+3.472	<.001	.002	3	3
UCEC	EXO1 →	+0.562	+2.332	.003	.003	3	3
UCEC	RTTN →	+0.445	+2.431	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,507 associations by consensus.

BUB3 by GPNMB expression — UCEC

Explore this box plot interactively →