GPNMB

Across TCGA patient cohorts, GPNMB mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPNMB-associated genes across cancer lineages are FoxM1, STAT3_pY705, and JNK2. Each is linked with GPNMB in more than 2 cancer types. Because this analysis shows association rather than direction, both GPNMB-to-partner and partner-to-GPNMB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by GPNMB-low versus GPNMB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPNMB→partner) and Y-score (partner→GPNMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.220	+2.201	.011	<.001	3	3
UCEC	STAT3_pY705 →	-0.425	-2.247	<.001	.001	3	3
UCEC	JNK2 →	+0.231	+2.201	<.001	<.001	3	2
UCEC	Notch1 →	+0.137	+1.710	.003	.025	3	2
UCEC	ATM →	-0.412	-2.000	.006	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.511	+1.926	.010	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

FoxM1 by GPNMB expression — UCEC

Explore this box plot interactively →