GPNMB

Across TCGA cell cohorts, GPNMB RNA expression is significantly associated with the go_rna of many other GO terms, with 4,968 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GPNMB-associated GO terms across cancer lineages are Endosome organization, Endoplasmic reticulum unfolded protein response, and Endosomal transport. Each is linked with GPNMB in more than 12 cancer types. Because this analysis shows association rather than direction, both GPNMB-to-partner and partner-to-GPNMB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosome organization grouped by GPNMB-low versus GPNMB-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPNMB→partner) and Y-score (partner→GPNMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Endosome organization →	+0.063	+2.606	.007	<.001	3	13
BONE	Endoplasmic reticulum unfolded protein response →	+0.090	+5.571	<.001	<.001	3	12
BONE	Endosomal transport →	+0.049	+3.386	<.001	<.001	3	11
SOFT_TISSUE	Lysosomal transport →	+0.061	+3.668	<.001	<.001	3	11
SOFT_TISSUE	Response to unfolded protein →	+0.090	+3.945	<.001	<.001	3	10
BONE	Response to acid chemical →	+0.075	+4.244	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,968 associations by consensus.

Endosome organization by GPNMB expression — KIDNEY

Explore this box plot interactively →