GPN3

Across TCGA pan-cancer cohorts, GPN3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GPN3 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher GPN3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GPN3 expression acts as an unfavorable survival marker.

DLBC, UCEC, and BLCA are the cancer types where GPN3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Median	All	0.054	0.842	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
BLCA	DFS	Median	II,III,IV	0.153	0.615	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GPN3–DLBC (OS)

Open the DLBC breakdown →