GPN3

Across TCGA pan-cancer cohorts, GPN3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GPN3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GPN3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPN3 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where GPN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.158	<.001	11	view →
HNSC	Male	III,IV	+0.719	<.001	11	view →
LIHC	All	III,IV	+0.781	<.001	8	view →
STAD	All	II,III,IV	+0.576	.001	6	view →
BLCA	All	All	+0.370	.003	6	view →
KICH	All	All	−0.935	<.001	5	view →
READ	All	II,III,IV	+0.882	.006	4	view →
LUSC	Male	II,III,IV	+0.452	<.001	4	view →
THCA	All	All	−0.245	.002	4	view →
ESCA	All	All	+0.823	<.001	3	view →
CHOL	All	All	+0.751	.003	2	view →
UCEC	All	All	−0.480	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GPN3–COAD

Open the COAD breakdown →