GPN3

Across TCGA pan-cancer cohorts, GPN3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GPN3 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GPN3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GPN3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, UCEC, and PDAC are the cancer types where GPN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.846	0.642	.008	19	view →
UCEC	DFS	Tertile	All	0.787	0.953	.023	14	view →
PDAC	DFS	Median	IV	0.282	0.934	.024	12	view →
GBM	OS	Tertile	All	0.646	0.420	.029	4	view →
LUAD	OS	Median	II,III,IV	1.000	0.807	.010	4	view →
LSCC	OS	Quartile	All	0.916	0.753	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GPN3–CCRCC (DFS)

Open the CCRCC breakdown →