GPM6B

Across TCGA pan-cancer cohorts, GPM6B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GPM6B data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GPM6B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GPM6B expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

UCEC, LSCC, and HNSC are the cancer types where GPM6B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.677	1.000	.025	8	view →
LSCC	DFS	Tertile	All	0.870	0.962	.007	7	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.872	.031	4	view →
LUAD	DFS	Median	All	0.853	1.000	.021	3	view →
GBM	DFS	Quartile	All	0.257	0.539	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GPM6B–UCEC (OS)

Open the UCEC breakdown →