GPM6B

Across TCGA pan-cancer cohorts, GPM6B RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of GPM6B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GPM6B RNA is repressed in tumor relative to normal tissue. In most cancer types GPM6B is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and COAD are the cancer types where GPM6B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPM6B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.318	<.001	12	view →
KICH	Male	All	−3.009	<.001	11	view →
COAD	Male	II,III,IV	−1.843	<.001	11	view →
THCA	Male	III,IV	−1.541	<.001	11	view →
BLCA	All	IV	−1.802	<.001	10	view →
LUAD	Female	III,IV	−2.400	<.001	9	view →
LUSC	Female	II,III,IV	−2.115	<.001	8	view →
STAD	All	All	−1.723	<.001	7	view →
BRCA	All	III,IV	−1.780	<.001	6	view →
KIRP	All	All	−0.879	.001	6	view →
CHOL	All	All	+0.957	<.001	5	view →
READ	Female	All	−3.406	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

GPM6B–KIRC

Open the KIRC breakdown →