GPM6B

Across TCGA patient cohorts, GPM6B mutation is significantly associated with the RNA expression of many other genes, with 2,540 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPM6B-associated genes across cancer lineages are RN7SL215P, TVP23BP2, and RN7SL134P. Each is linked with GPM6B in more than 1 cancer types. Because this analysis shows association rather than direction, both GPM6B-to-partner and partner-to-GPM6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL215P grouped by GPM6B-low versus GPM6B-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPM6B→partner) and Y-score (partner→GPM6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL215P →	+0.322	+5.080	<.001	.001	3	2
COAD	TVP23BP2 →	+0.565	+4.602	<.001	.008	3	2
SKCM	RN7SL134P →	+0.162	+5.118	<.001	.001	3	2
UCEC	RNA5SP248 →	+0.276	+1.391	<.001	.005	3	2
UCEC	RNA5SP451 →	+0.180	+2.129	<.001	.005	3	2
UCEC	TSPY25P →	+0.007	+3.896	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,540 associations by consensus.

RN7SL215P by GPM6B expression — BRCA

Explore this box plot interactively →