GPM6B

Across TCGA patient cohorts, GPM6B mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPM6B-associated genes across cancer lineages are Rab25, STAT3_pY705, and Caspase-7-cleavedD198. Each is linked with GPM6B in more than 1 cancer types. Because this analysis shows association rather than direction, both GPM6B-to-partner and partner-to-GPM6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by GPM6B-low versus GPM6B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPM6B→partner) and Y-score (partner→GPM6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.258	-1.678	.014	.021	3	2
UCEC	STAT3_pY705 →	-0.255	-1.502	.002	.025	3	2
UCEC	Caspase-7-cleavedD198 →	+0.397	+1.785	.036	.007	3	2
UCEC	14-3-3_beta →	-0.079	-1.558	.013	.032	3	1
UCEC	EGFR_pY1068 →	-0.275	-3.999	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.098	-1.289	.010	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Rab25 by GPM6B expression — UCEC

Explore this box plot interactively →