GPM6A

Across TCGA patient cohorts, GPM6A protein abundance is significantly associated with the RNA expression of many other genes, with 6,543 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GPM6A-associated genes across cancer lineages are SEMA3G, SSTR1, and SNCA. Each is linked with GPM6A in more than 2 cancer types. Because this analysis shows association rather than direction, both GPM6A-to-partner and partner-to-GPM6A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPM6A versus SEMA3G in GBM, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPM6A→partner) and Y-score (partner→GPM6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEMA3G →	+0.461	+0.477	<.001	<.001	3	3
GBM	SSTR1 →	+0.602	+0.654	<.001	<.001	3	3
GBM	SNCA →	+1.189	+0.676	<.001	<.001	3	3
LUAD	CA4 →	+0.879	+0.877	<.001	<.001	3	3
GBM	FAM107A →	+1.378	+0.715	<.001	<.001	3	3
LSCC	SFTPC →	+3.377	+0.464	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,543 associations by consensus.

GPM6A vs SEMA3G — GBM

Explore this scatter interactively →