GPM6A

Across TCGA pan-cancer cohorts, GPM6A RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of GPM6A’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GPM6A RNA is repressed in tumor relative to normal tissue. In most cancer types GPM6A is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and COAD are the cancer types where GPM6A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPM6A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−3.474	<.001	11	view →
KICH	Female	All	−3.199	<.001	11	view →
COAD	Male	II,III,IV	−2.272	<.001	11	view →
LUAD	Female	III,IV	−4.749	<.001	9	view →
LUSC	Female	II,III,IV	−4.745	<.001	9	view →
KIRP	Female	All	−1.756	<.001	9	view →
LIHC	Male	III,IV	−1.678	<.001	8	view →
KIRC	Male	II,III,IV	−1.234	<.001	8	view →
STAD	All	All	−0.986	<.001	8	view →
BLCA	All	IV	−1.405	.001	7	view →
UCEC	All	All	−2.495	<.001	6	view →
HNSC	All	All	−0.178	.014	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

GPM6A–THCA

Open the THCA breakdown →