GPM6A

Across TCGA patient cohorts, GPM6A mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPM6A-associated genes across cancer lineages are Notch1, Annexin-1, and TFRC. Each is linked with GPM6A in more than 1 cancer types. Because this analysis shows association rather than direction, both GPM6A-to-partner and partner-to-GPM6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by GPM6A-low versus GPM6A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPM6A→partner) and Y-score (partner→GPM6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.122	+1.241	.003	.015	3	2
UCEC	Annexin-1 →	+0.432	+1.604	.005	.010	3	2
UCEC	TFRC →	+0.368	+2.000	.018	.029	3	2
UCEC	ASNS →	+0.534	+1.857	<.001	<.001	3	2
UCEC	ATM →	-0.486	-1.637	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.079	-1.973	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Notch1 by GPM6A expression — UCEC

Explore this box plot interactively →