GPM6A

Across TCGA cell cohorts, GPM6A mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPM6A-associated genes across cancer lineages are NT5C1A, MSGN1, and GSTA3. Each is linked with GPM6A in more than 1 cancer types. Because this analysis shows association rather than direction, both GPM6A-to-partner and partner-to-GPM6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NT5C1A grouped by GPM6A-low versus GPM6A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPM6A→partner) and Y-score (partner→GPM6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NT5C1A →	+0.042	+3.684	<.001	.006	3	1
LARGE_INTESTINE	MSGN1 →	+0.106	+3.930	<.001	.003	3	1
LARGE_INTESTINE	GSTA3 →	+0.088	+3.684	.005	.006	3	1
LARGE_INTESTINE	CENPVL1 →	+0.201	+4.510	<.001	.001	3	1
LARGE_INTESTINE	CENPVL3 →	+0.391	+3.920	<.001	.005	3	1
LARGE_INTESTINE	OR4A47 →	+0.018	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

NT5C1A by GPM6A expression — LARGE_INTESTINE

Explore this box plot interactively →