GPKOW

Across TCGA patient cohorts, GPKOW mutation is significantly associated with the RNA expression of many other genes, with 2,398 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPKOW-associated genes across cancer lineages are RNU6-923P, GEMIN8P3, and RNU1-143P. Each is linked with GPKOW in more than 1 cancer types. Because this analysis shows association rather than direction, both GPKOW-to-partner and partner-to-GPKOW results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-923P grouped by GPKOW-low versus GPKOW-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPKOW→partner) and Y-score (partner→GPKOW) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-923P →	+0.314	+5.571	<.001	.002	3	2
BRCA	GEMIN8P3 →	+0.053	+5.016	<.001	.005	3	2
BRCA	RNU1-143P →	+0.349	+5.639	<.001	.002	3	2
LUSC	MIR548J →	+0.439	+4.339	.001	.007	3	2
LUSC	LINC01848 →	+0.477	+4.447	<.001	.006	3	2
LUSC	USP21P2 →	+0.053	+5.309	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,398 associations by consensus.

RNU6-923P by GPKOW expression — BRCA

Explore this box plot interactively →